IN VITRO EVALUATION OF THE ANTHELMINTIC ACTIVITY OF RHIZOME EXTRACTS OF CURCUMA LONGA (LINN.)

Objective: The current study was carried out to evaluate the anthelmintic activity of the rhizome extract of Curcuma longa as an alternative source of effective remedies for nematodiasis.Methods: The anthelmintic activity of the C. longa was assessed in vitro against Haemonchus spp., a gastrointestinal (abomasum) parasite of goats. Different concentrations of the extracts (1 mg/mL, 2.5 mg/mL, 5 mg/mL, and 10 mg/mL) in phosphate-buffered saline (PBS) were tested, and the results expressed in terms of time of paralysis (minute) and time of death (minute) of the worms. Albendazole (1 mg/mL) was used as a reference (positive control) and PBS as a control group (negative control).Results: The qualitative phytochemical analysis of the methanolic extract (ME) of the plant disclosed the presence of alkaloids, glycosides, terpenoids, flavonoids, tannins, saponins, phenol, anthraquinone, and carbohydrates; whereas, the aqueous extract (AE) showed the presence of alkaloids, carbohydrate, flavonoids, and saponins. Both ME and AE of the C. longa (rhizome) expressed significant efficacy (p≤0.05) in causing paralysis as well as the death of the worms within 12 h of exposure at all tested concentrations, as compared to the negative control. The rhizome extracts of C. longa showed dose-dependent efficacy in causing paralysis of the worm motility and the final progression to death. The results showed that the ME at 10 mg/mL was significantly more potent (p≤0.05) over the AE.Conclusions: This study concluded that the rhizome extract of C. longa exhibited potent anthelmintic efficacy against the nematode parasite, Haemonchus spp

A Method of Transformation for Generalized Hypergeometric Function 2F2

By employing an addition theorem for the confluent hypergeometric function, Paris R.B.[3], has obtained a Kummer-type transformation for a 2F2 (x) hypergeometric function with general parameters in the form of a sum of 2F2 (-x) functions. Recently, Choi Junesang and Rathie Arjun K.[1], has obtained the same result without using the addition theorem. The aim of this paper is to derive the result of Paris R.B.[3], with change in the general parameters without using the addition theorem in the line of Choi Junesang and Rathie Arjun K.[1]. Corresponding author E.mail:- [email protected], [email protected]

Some cases of reducible Generalized Hypergeometric Functions

In this paper we consider the integrals of Generalized hypergeometric function of three variables given by Saran Shanti [4] and obtained  functions of two variables of Horn’s list given in  ErdelyiA.[1]. Our results are also motivated by Singh Pooja & Singh Prof. (Dr.) Harish [3]